Showing 136–144 of 146 results
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Recombinant Human CAMKK1 (N-GST tag)
Product Details
Gene ID N/A Accession NM_032294 Alternative Name CAMKKA, MGC34095, DKFZp761M0423 Species Human Source Insect cells Description ?CAMKK1 or CAMKKa is a Ca(2+)/calmodulin-dependent protein kinase that activates CaM-kinases I and IV via phosphorylation of their Thr(177) and Thr(196) residues, respectively. Recent studies have shown that the activity of CAMKK1 is decreased upon phosphorylation by cAMP-dependent protein kinase (PKA) The CAMKKalpha has been identified in intact cells as AMPKKs, predicting a significant role for this kinase in regulating AMPK activity in vivo. It has been shown that 2-deoxyglucose- and ionomycin-stimulated AMPK activity is substantially reduced in HeLa cells transfected with small interfering RNAs specific for CAMKKa . Accession NM_032294 Functions The specific activity of CAMKK1 was determined to be 10 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 94 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CAMKK2 (N-GST tag)
Product Details
Gene ID N/A Accession NM_172226 Alternative Name CAMKK; CAMKKB; KIAA0787; MGC15254 Species Human Source Insect cells Description CAMKK2 (CAMKK?) is a member of the CAMKK family. It is broadly distributed in tissues with highest levels in brain, thymus, spleen, and testis . CaMKK2 undergoes intramolecular autophosphorylation, is regulated by Ca2+/calmodulin and phosphorylates CaMKI and CaMKIV on Thr177 and Thr200, respectively. CaMKK2 activates both CaMKI and CaMKIV when coexpressed in Jurkat T cells. CaMKK2 also phosphorylates and regulates the activity of AMPK, which is an important regulator of cellular metabolism in response to metabolic stress . Accession NM_172226 Functions The specific activity of CAMKK2 was determined to be 11 nmol /min/mgas per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 88 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human Cardiotrophin-1 (CT-1)
Product Details
Gene ID 1489 Accession Q16619 Alternative Name Recombinant Human Cardiotrophin-1, CTF1, CT1, CT-1 Species Human Source E. coli Description Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine. Accession Q16619 Functions ED50 is ? 0.5 ng/mL as determined by the dose-dependent TF-1 cell proliferation. Formulation Lyophilized from a 0.2 ?m filtered solution in PBS Solubility Reconstitute in sterile 20mM Tris, pH 8.0 at 100μg/mL (containing at least 0.1% human or bovine serum albumin). Further dilutions should be made in aqueous buffers supplemented with carrier protein, such as 0.1?1.0% BSA. Appearance Lyophilized Powder Molecular Weight 21 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Cardiotrophin-1 (CT-1)
Product Details
Gene ID 1489 Accession Q16619 Alternative Name Recombinant Human Cardiotrophin-1, CTF1, CT1, CT-1 Species Human Source E. coli Description Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine. Accession Q16619 Functions ED50 is ? 1.0 ng/mL as determined by the dose-dependent TF-1 cell proliferation Formulation Lyophilized from a 0.2 ?m filtered solution in PBS Solubility Reconstitute in sterile HCl at 100μg/mL (containing at least 0.1% human or bovine serum albumin) Appearance Lyophilized Powder Molecular Weight 21 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Cardiotrophin-1 (CT-1)
Product Details
Gene ID 1489 Accession Q16619 Alternative Name Recombinant Human Cardiotrophin-1, CTF1, CT1, CT-1 Species Human Source E. coli Description Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine. Accession Q16619 Functions ED50 is ? 1.0 ng/mL as determined by the dose-dependent TF-1 cell proliferation Formulation Lyophilized from a 0.2 ?m filtered solution in PBS Solubility Reconstitute in sterile HCl at 100μg/mL (containing at least 0.1% human or bovine serum albumin) Appearance Lyophilized Powder Molecular Weight 21 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human CASK (N-GST tag)
Product Details
Gene ID N/A Accession NM_003688 Alternative Name CAGH39; CAMGUK; CMG; FGS4; LIN2; MICPCH; TNRC8 Species Human Source Insect cells Description CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member . CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton . Accession NM_003688 Functions The specific activity of CASK was determined to be 3 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 95 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CCL2
Product Details
Gene ID 6347 Accession P13500 Alternative Name Monocyte Chemotactic Protein-1, MCP-1, CCL2, MCAF, C-C motif chemokine 2, HC11, Monocyte chemotactic and activating factor, Monocyte secretory protein JE, Small-inducible cytokine A2, MCP1, SCYA2<br/>Recombinant Human Monocyte Chemoattractant Protein-1 (CCL2) Species Human Source E. coli Description MCP-1 belongs to the family of chemotactic cytokines. MCP-1 is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cell, and osteoblastic cells. MCP-1 has been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK. Elevated levels of MCP-1 are observed in atherosclerotic plaques that are rich in macrophages. The factor activates the tumoricidal activity of monocytes and macrophages in vivo. It regulates the expression of cell surface antigens (CD11c, CD11b) and the expression of cytokines (IL-1, IL-6). MCP-1 is a potent activator of human basophils, inducing degranulation and the release of histamines. In basophils activated by IL-3, IL-5 or GM-CSF MCP-1 enhances the synthesis of leukotriene C4. Accession P13500 Functions The ED(50) was determined by the dose-dependent proliferation of PC3 cells and was found to be <0.2ng/mL. Formulation MCP-1 was lyophilized from PBS pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 9 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition This cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human CCL2
Product Details
Gene ID 6347 Accession P13500 Alternative Name Monocyte Chemotactic Protein-1, MCP-1, CCL2, MCAF, C-C motif chemokine 2, HC11, Monocyte chemotactic and activating factor, Monocyte secretory protein JE, Small-inducible cytokine A2, MCP1, SCYA2<br/>Recombinant Human Monocyte Chemoattractant Protein-1 (CCL2) Species Human Source E. coli Description MCP-1 belongs to the family of chemotactic cytokines. MCP-1 is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cell, and osteoblastic cells. MCP-1 has been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK. Elevated levels of MCP-1 are observed in atherosclerotic plaques that are rich in macrophages. The factor activates the tumoricidal activity of monocytes and macrophages in vivo. It regulates the expression of cell surface antigens (CD11c, CD11b) and the expression of cytokines (IL-1, IL-6). MCP-1 is a potent activator of human basophils, inducing degranulation and the release of histamines. In basophils activated by IL-3, IL-5 or GM-CSF MCP-1 enhances the synthesis of leukotriene C4. Accession P13500 Functions The ED(50) was determined by the dose-dependent proliferation of PC3 cells and was found to be <0.2ng/mL. Formulation MCP-1 was lyophilized from PBS pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 9 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition This cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Proteins
Product Details
Gene ID gene_id Accession accession Alternative Name alternative_name Species species Source source Description description Accession accession Functions functions Formulation formulation Solubility solubility Appearance appearance Molecular Weight molecular_weight Purity purity Concentration concentration Shipping Condition shipping_condition Storage Condition storage_condition $0.00(3)