Showing 127–135 of 142 results
-
Recombinant Human CAMK2 delta (N-GST tag)
Product Details
Gene ID N/A Accession NM_172115 Alternative Name CAMKD, MGC44911 Species Human Source Insect cells Description CAMK2D is a serine/threonine protein kinase that is a member of the type II multifunctional Ca2+/calmodulin-dependent protein kinase family. CAMK2D is abundantly present in human cardiac and skeletal muscle and its levels are increased in the heart of patients suffering from cardiomyopathy . In cardiomyocytes, stimulation of beta-1-adrenergic receptor leads to induction of apoptosis, an effect that is mediated by activation of CAMK2D in a PKA-independent manner. In addition, expression studies have revealed the downregulation of CAMK2D in human tumor cells. Accession NM_172115 Functions The specific activity of CAMK2? was determined to be 5,860 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 77 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CAMK2 gamma (N-GST tag)
Product Details
Gene ID N/A Accession NM_172169 Alternative Name CAMKG, CAMK, CAMK-II, MGC26678 Species Human Source Insect cells Description CAMK2? is a member of the CAMKII family which are ubiquitous serine/threonine protein kinases that have been implicated in diverse effects of hormones and neurotransmitters. CAMK2? has six alternatively spliced variants that encode six different isoforms. Some of these variants have been identified in human tumors . Transgenic mice expressing a partially calcium-independent mutant form of CAMKG showed 1.5- to 2-fold increase in the thymus of these mice, at least in part due to an increase in the life span of double-positive thymocytes . There was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype. Accession NM_172169 Functions The specific activity of CAMK2? was determined to be 248 nmol /min/mg as per activity assay protocol Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 60 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CAMK2beta (N-GST tag)
Product Details
Gene ID N/A Accession NM_172081 Alternative Name CAMKB, CAM2, CAMK2, MGC29528 Species Human Source Insect cells Description CAMK2beta belongs to the serine/threonine protein kinase family and to the type II multifunctional Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK2beta showed wide tissue and cell distribution, and one of CAMK2beta variant predominated in adult brain . The ratio of CAMK2alpha and CAMK2beta protein levels were inversely related during activity in hippocampal neurons . CAMK2beta is a prominent kinase in the central nervous system and may function in long-term potentiation and neurotransmitter release. Accession NM_172081 Functions The specific activity of CAMK2? was determined to be 1,700 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 81 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CAMK2gamma (N-GST tag)
Product Details
Gene ID N/A Accession NM_172169 Alternative Name CAMKG, CAMK, CAMK-II, MGC26678 Species Human Source Insect cells Description CAMK2gamma is a member of the CAMKII family which are ubiquitous serine/threonine protein kinases that have been implicated in diverse effects of hormones and neurotransmitters. CAMK2gamma has six alternatively spliced variants that encode six different isoforms. Some of these variants have been identified in human tumors . Transgenic mice expressing a partially calcium-independent mutant form of CAMK2gamma showed 1.5- to 2-fold increase in the thymus of these mice, at least in part due to an increase in the life span of double-positive thymocytes . There was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype. Accession NM_172169 Functions The specific activity of CAMK2? was determined to be 260 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 86 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CAMK4 (N-GST tag)
Product Details
Gene ID N/A Accession NM_001744 Alternative Name CaMK-GR; MGC36771 Species Human Source Insect cells Description CAMK4 is a multifunctional serine/threonine protein kinase and a member of Ca(2+)/calmodulin- dependent protein kinase family. CAMK4 is localized in neurons in the hippocampus, amygdala, anterior cingulate cortex, somatosensory cortex, and insular cortex . CAMK4 is involved in neural activity-dependent signaling in the neuronal nucleus and thought to plays an important role in the consolidation/retention of hippocampus-dependent long-term memory .? Accession NM_001744 Functions The specific activity of CAMK4 was determined to be 92 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 79 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CAMKK1 (N-GST tag)
Product Details
Gene ID N/A Accession NM_032294 Alternative Name CAMKKA, MGC34095, DKFZp761M0423 Species Human Source Insect cells Description ?CAMKK1 or CAMKKa is a Ca(2+)/calmodulin-dependent protein kinase that activates CaM-kinases I and IV via phosphorylation of their Thr(177) and Thr(196) residues, respectively. Recent studies have shown that the activity of CAMKK1 is decreased upon phosphorylation by cAMP-dependent protein kinase (PKA) The CAMKKalpha has been identified in intact cells as AMPKKs, predicting a significant role for this kinase in regulating AMPK activity in vivo. It has been shown that 2-deoxyglucose- and ionomycin-stimulated AMPK activity is substantially reduced in HeLa cells transfected with small interfering RNAs specific for CAMKKa . Accession NM_032294 Functions The specific activity of CAMKK1 was determined to be 10 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 94 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human CAMKK2 (N-GST tag)
Product Details
Gene ID N/A Accession NM_172226 Alternative Name CAMKK; CAMKKB; KIAA0787; MGC15254 Species Human Source Insect cells Description CAMKK2 (CAMKK?) is a member of the CAMKK family. It is broadly distributed in tissues with highest levels in brain, thymus, spleen, and testis . CaMKK2 undergoes intramolecular autophosphorylation, is regulated by Ca2+/calmodulin and phosphorylates CaMKI and CaMKIV on Thr177 and Thr200, respectively. CaMKK2 activates both CaMKI and CaMKIV when coexpressed in Jurkat T cells. CaMKK2 also phosphorylates and regulates the activity of AMPK, which is an important regulator of cellular metabolism in response to metabolic stress . Accession NM_172226 Functions The specific activity of CAMKK2 was determined to be 11 nmol /min/mgas per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 88 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human Cardiotrophin-1 (CT-1)
Product Details
Gene ID 1489 Accession Q16619 Alternative Name Recombinant Human Cardiotrophin-1, CTF1, CT1, CT-1 Species Human Source E. coli Description Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine. Accession Q16619 Functions ED50 is ? 0.5 ng/mL as determined by the dose-dependent TF-1 cell proliferation. Formulation Lyophilized from a 0.2 ?m filtered solution in PBS Solubility Reconstitute in sterile 20mM Tris, pH 8.0 at 100μg/mL (containing at least 0.1% human or bovine serum albumin). Further dilutions should be made in aqueous buffers supplemented with carrier protein, such as 0.1?1.0% BSA. Appearance Lyophilized Powder Molecular Weight 21 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Cardiotrophin-1 (CT-1)
Product Details
Gene ID 1489 Accession Q16619 Alternative Name Recombinant Human Cardiotrophin-1, CTF1, CT1, CT-1 Species Human Source E. coli Description Cardiotrophin-1 is a pleiotrophic cytokine and is a member of the IL-6 cytokine family that also includes IL6, IL11, LIF, OSM, CLC and IL31.Full length human CT-1 shares a 79% amino acid sequence identity with murinic CT-1 and both lack a canonical signal sequence. Cardiotrophin-1 interacts with the leukemia inhibitory factor receptor (LIFR) heterodimer and the glycoprotein 130 subunit (gp130) and has the ability to induce cardiac myocyte hypertrophy. It is highly expressed in various skeletal muscles and cardiac tissue, as well as the colon, ovary and prostate, liver, and pancreas, while lower expression levels are found in the lungs, kidney, pancreas, testis, and small intestine. Accession Q16619 Functions ED50 is ? 1.0 ng/mL as determined by the dose-dependent TF-1 cell proliferation Formulation Lyophilized from a 0.2 ?m filtered solution in PBS Solubility Reconstitute in sterile HCl at 100μg/mL (containing at least 0.1% human or bovine serum albumin) Appearance Lyophilized Powder Molecular Weight 21 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No)