Showing 109–117 of 146 results
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Recombinant Human Beta-NGF
Product Details
Gene ID 4803 Accession P01138 Alternative Name ?-NGF, Nerve Growth Factor Species Human Source E. coli Description ?-NGF is a potent neurotrophic factor that plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. ?-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. ?-NGF belongs to the cysteine-knot family of growth factors that assume stable, disulfide-linked homodimeric structures. Recombinant human ?-NGF shares approximately 90% homology with both the mouse and rat ?NGF at the primary level. Accession P01138 Functions N.A. Formulation N.A. Solubility Reconstitute at 0.1mg/ml in sterile PBS Appearance Lyophilized Powder Molecular Weight 14 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human BLK (N-GST tag)
Product Details
Gene ID N/A Accession BC007371 Alternative Name MGC10442 Species Human Source Insect cells Description BLK, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. BLK is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells . Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of BLK .? Accession BC007371 Functions The specific activity of BLK was determined to be 112 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 84 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human BMP-3 beta (GDF10)
Product Details
Gene ID 2662 Accession P55107 Alternative Name BMP-3B, BMP3, BIP, Growth/differentiation factor 10, GDF-10<br/>Recombinant Human Bone Morphogenetic Protein 3B (GDF10) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP3 is a glycoprotein that is identical with osteogenin. Human and rat mature proteins are 98% identical. Accession P55107 Functions Not available. Formulation Recombinant BMP-3b was lyophilized from a 0.2 ?m filtered 1.0 mg/mL 10 mM sodium citrate (pH 3.5) containing 10% glycerol. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 13 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months. Avoid repeated freeze/thaw cycle. $0.00(No) -
Recombinant Human BMP-3 beta (GDF10)
Product Details
Gene ID 2662 Accession P55107 Alternative Name BMP-3B, BMP3, BIP, Growth/differentiation factor 10, GDF-10<br/>Recombinant Human Bone Morphogenetic Protein 3B (GDF10) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP3 is a glycoprotein that is identical with osteogenin. Human and rat mature proteins are 98% identical. Accession P55107 Functions Not available. Formulation Recombinant BMP-3b was lyophilized from a 0.2 ?m filtered 1.0 mg/mL 10 mM sodium citrate (pH 3.5) containing 10% glycerol. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 13 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months. Avoid repeated freeze/thaw cycle. $0.00(No) -
Recombinant Human BMP2
Product Details
Gene ID 650 Accession P12643 Alternative Name BMP-2, BMP-2A<br/>Recombinant Human Bone Morphogenetic Protein 2 (BMP2) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP-2 wild type binds to its cellular receptors via two distinct binding epitopes. The large epitope 1 is responsible for the high-affinity binding to the BMPR-IA receptor, the smaller epitope 2 provides the low-affinity binding to the receptor BMPR-II. Recombinant Human Bone Morphogenetic Protein-2 is a homodimeric, non-glycosylated polypeptide chain containing two 115 amino acid subunits with a total molecular mass of 26kDa. Accession P12643 Functions The ED50 as determined by its ability to induce alkaline phosphatase production by C2C12 myogenic cells was found to be less than 50 ng/mL Formulation Lyophilized from a 0.2 ?m filtered solution in 20 mM AcOH pH 6.5 Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 26 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human BMP2
Product Details
Gene ID 650 Accession P12643 Alternative Name BMP-2, BMP-2A<br/>Recombinant Human Bone Morphogenetic Protein 2 (BMP2) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP-2 wild type binds to its cellular receptors via two distinct binding epitopes. The large epitope 1 is responsible for the high-affinity binding to the BMPR-IA receptor, the smaller epitope 2 provides the low-affinity binding to the receptor BMPR-II. Recombinant Human Bone Morphogenetic Protein-2 is a homodimeric, non-glycosylated polypeptide chain containing two 115 amino acid subunits with a total molecular mass of 26kDa. Accession P12643 Functions The ED(50) was determined by its ability to induce alkaline phosphatase production by C2C12 myogenic cells was found to be less than 50 ng/mL. Formulation Recombinant Human Bone Morphogenetic Protein-2 was lyophilized from a 0.2 ?m filtered solution in 20 mM AcOH pH 6.5. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 26 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human BMP4
Product Details
Gene ID 652 Accession P12644 Alternative Name BMP-4, BMP-2B, DVR4<br/>Recombinant Human Bone Morphogenetic Protein 4 (BMP4) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They not only promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signalling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP4 and BMP7 are also known to be involved in the differentiation of sympathetic neurons. BMP4 is a disulfide linked homodimer that is expressed majorly in the lungs but also found in the kidneys, normal and neoplastic prostate tissues, and prostate cancer cell lines. Accession P12644 Functions The ED50 as determined by its ability to induce alkaline phosphatase production in mouse ATDC5 chondrogenic was found to be in the range of 0.1-0.2 ug/mL Formulation Lyophilized from a 0.2 ?m filtered solution in Sodium carbonate (pH 9) Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 13 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human BMP4
Product Details
Gene ID 652 Accession P12644 Alternative Name BMP-4, BMP-2B, DVR4<br/>Recombinant Human Bone Morphogenetic Protein 4 (BMP4) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They not only promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signalling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP4 and BMP7 are also known to be involved in the differentiation of sympathetic neurons. BMP4 is a disulfide linked homodimer that is expressed majorly in the lungs but also found in the kidneys, normal and neoplastic prostate tissues, and prostate cancer cell lines. Accession P12644 Functions The ED(50) was determined by its ability to induce alkaline phosphatase production in mouse ATDC5 chondrogenic and was found to be in the range of 0.1-0.2 ug/mL. Formulation Lyophilized from a 0.2 ?m filtered solution in 20 mM Sodium carbonate (pH 9). Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 13 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human BMP7
Product Details
Gene ID 655 Accession P18075 Alternative Name Osteogenic protein 1, OP-1, INN=Eptotermin alfa, BMP7 <br/>Recombinant Human Bone Morphogenetic Protein 7 (BMP7) Species Human Source E. coli Description BMP-7(osteogenic protein- 1) is produced in the kidney and in the nervous system. It is produced also by human fetal trophoblasts in vivo and may be involved in the regulation of the synthesis of chorionic gonadotropin and progesterone by trophoblasts. BMP7 induces new bone growth, and forms heterodimers with BMP2A. The factor is a member of the TGF family of proteins. Accession P18075 Functions Not available. Formulation Recombinant BMP-7 was lyophilized from a 0.2 ?m filtered PBS solution pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 17 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No)