Showing 100–108 of 142 results
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Recombinant Human Beta-Defensin 4 (DEFB104A)
Product Details
Gene ID 140596 Accession Q8WTQ1 Alternative Name BD-4, DEFB-4, hBD-4, Defensin, beta 104, DEFB104, DEFB4, DEFB104A Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so forms channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession Q8WTQ1 Functions The ED(50) was determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/mL. Formulation Recombinant Human Beta Defensin-4 was lyophilized from 0.2 ?m filtered 100 mM NaCl, 20 mM PB, pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 6 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 4 (DEFB104A)
Product Details
Gene ID 140596 Accession Q8WTQ1 Alternative Name BD-4, DEFB-4, hBD-4, Defensin, beta 104, DEFB104, DEFB4, DEFB104A Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so forms channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession Q8WTQ1 Functions The ED(50) was determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/mL. Formulation Recombinant Human Beta Defensin-4 was lyophilized from 0.2 ?m filtered 100 mM NaCl, 20 mM PB, pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 6 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 4 (DEFB104A)
Product Details
Gene ID 140596 Accession Q8WTQ1 Alternative Name BD-4, DEFB-4, hBD-4, Defensin, beta 104, DEFB104, DEFB4, DEFB104A Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so forms channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession Q8WTQ1 Functions The ED(50) was determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/mL. Formulation Recombinant Human Beta Defensin-4 was lyophilized from 0.2 ?m filtered 100 mM NaCl, 20 mM PB, pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 6 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-NGF
Product Details
Gene ID 4803 Accession P01138 Alternative Name NGF, NGFB<br/>Recombinant Human NGF Species Human Source CHO cells Description NGF is mainly responsible for the survival and the differentiation and the functional activities of sensory and sympathetic neurons in the peripheral nervous system. It also plays an important role in the development and functional activities of cholinergic neurons in the central nervous system. Since NGF is synthesized also in non-neuronal tissues it may have a much wider spectrum of biological activities than thought previously. NGF stimulates chemotactic migration of human polymorphonuclear leukocytes in vitro. NGF stimulates the growth and differentiation of B cells and the growth of T cells and of some tumor cell types. NGF inhibits immunoglobulin production by various human plasma cell. The cytokines IL-1, IL-6, and bFGF are potent inducers of NGF. NGF induces the synthesis of IL-1 in pheochromocytoma cells which in turn acts as a growth factor for glial cells and induces the synthesis of NGF following nerve injuries. In thymic stromal cells NGF induces the synthesis of IL-6. NGF induces the synthesis of the fos oncogene and the myc oncogene and also influences the expression of EGF. One receptor that is responsible for mediating most of the activities of NGF is expressed preferentially in neuronal tissues. This glycoprotein of 140 kDa is the product of the trk gene. It possesses an intrinsic tyrosine-specific protein kinase in its intracellular domain. Accession P01138 Functions The ED(50) was determined by the determined by its ability to proliferate TF-1 cells and was found to be in the range of 0.5 ng/mL. Formulation NGF-beta was lyophilized from a 0.2 ?m filtered solution in 20 mM sodium acetate, 150 mM NaCl, pH 5.5. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 27 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-NGF
Product Details
Gene ID 4803 Accession P01138 Alternative Name ?-NGF, Nerve Growth Factor Species Human Source E. coli Description ?-NGF is a potent neurotrophic factor that plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. ?-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. ?-NGF belongs to the cysteine-knot family of growth factors that assume stable, disulfide-linked homodimeric structures. Recombinant human ?-NGF shares approximately 90% homology with both the mouse and rat ?NGF at the primary level. Accession P01138 Functions N.A. Formulation N.A. Solubility Reconstitute at 0.1mg/ml in sterile PBS Appearance Lyophilized Powder Molecular Weight 14 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-NGF
Product Details
Gene ID 4803 Accession P01138 Alternative Name ?-NGF, Nerve Growth Factor Species Human Source E. coli Description ?-NGF is a potent neurotrophic factor that plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. ?-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. ?-NGF belongs to the cysteine-knot family of growth factors that assume stable, disulfide-linked homodimeric structures. Recombinant human ?-NGF shares approximately 90% homology with both the mouse and rat ?NGF at the primary level. Accession P01138 Functions N.A. Formulation N.A. Solubility Reconstitute at 0.1mg/ml in sterile PBS Appearance Lyophilized Powder Molecular Weight 14 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human BLK (N-GST tag)
Product Details
Gene ID N/A Accession BC007371 Alternative Name MGC10442 Species Human Source Insect cells Description BLK, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. BLK is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells . Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of BLK .? Accession BC007371 Functions The specific activity of BLK was determined to be 112 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 84 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. $0.00(No) -
Recombinant Human BMP-3 beta (GDF10)
Product Details
Gene ID 2662 Accession P55107 Alternative Name BMP-3B, BMP3, BIP, Growth/differentiation factor 10, GDF-10<br/>Recombinant Human Bone Morphogenetic Protein 3B (GDF10) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP3 is a glycoprotein that is identical with osteogenin. Human and rat mature proteins are 98% identical. Accession P55107 Functions Not available. Formulation Recombinant BMP-3b was lyophilized from a 0.2 ?m filtered 1.0 mg/mL 10 mM sodium citrate (pH 3.5) containing 10% glycerol. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 13 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months. Avoid repeated freeze/thaw cycle. $0.00(No) -
Recombinant Human BMP-3 beta (GDF10)
Product Details
Gene ID 2662 Accession P55107 Alternative Name BMP-3B, BMP3, BIP, Growth/differentiation factor 10, GDF-10<br/>Recombinant Human Bone Morphogenetic Protein 3B (GDF10) Species Human Source E. coli Description BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP3 is a glycoprotein that is identical with osteogenin. Human and rat mature proteins are 98% identical. Accession P55107 Functions Not available. Formulation Recombinant BMP-3b was lyophilized from a 0.2 ?m filtered 1.0 mg/mL 10 mM sodium citrate (pH 3.5) containing 10% glycerol. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 13 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months. Avoid repeated freeze/thaw cycle. $0.00(No)