Gene ID	N/A
Accession	NM_004333
Alternative Name	BRAF (Ex9-18), BRAF1, RAFB1, B-raf, B-raf 1, MGC126806, MGC138284
Species	Human
Source	Insect cells
Description	BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRAF in cells responding to growth factor signals . Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 599 within the activation segment of BRAF .
Accession	NM_004333
Functions	The specific activity of BRAF was determined to be 2,300 nmol/min/mg in a coupled assay as per activity assay protocol.
Formulation	50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Solubility	N/A
Appearance	Liquid
Molecular Weight	69
Purity	70% – 90%
Shipping Condition	Dry Ice
Storage Condition	Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.