Recombinant Human AURORA C (N-GST tag)
Product Details
| Gene ID | N/A |
| Accession | NM_003160 |
| Alternative Name | AURKC, AIE2, AIK3, AurC, STK13, aurora-C |
| Species | Human |
| Source | Insect cells |
| Description | Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors . Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development . |
| Accession | NM_003160 |
| Functions | The specific activity of AURORA C was determined to be 65 nmol /min/mg as per activity assay protocol |
| Formulation | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
| Solubility | N/A |
| Appearance | Liquid |
| Molecular Weight | 61 |
| Purity | 70% – 90% |
| Shipping Condition | Dry Ice |
| Storage Condition | Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
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