Gene ID	3604
Accession	Q07011
Alternative Name	Tumor necrosis factor receptor superfamily member 9, 41BB, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, CD137<br/>Recombinant Human 4-1BB (TNFRSF9)
Species	Human
Source	E. coli
Description	4-1BB Receptor (CD137) is a member of the TNF receptor superfamily expressed on activated CD4 and CD8 T cells as well as on activated natural killer cells. The binding of 4-1BB Receptor to its TNF family ligand, 4-1BB ligand (4-1BBL) delivers a co-stimulatory signal to resting T cells leading to high level IL2 production independently of CD28 signaling. Recombinant Human 4-1BB Receptor represents the soluble, cysteine-rich TNFR-like extracellular domain of 4-1BB Receptor.
Accession	Q07011
Functions	The ED50 as determined by dose dependent proliferation of human megakaryocytic leukemia cell line is <0.5ng/ml.
Formulation	Lyophilized from 0.2 ?m filtered solution in PBS (pH 7.5)
Solubility	A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Appearance	Lyophilized Powder
Molecular Weight	18
Purity	>95% as determined by SDS-PAGE
Concentration	<1.0 EU/μg of recombinant protein as determined by the LAL method
Shipping Condition	Ambient Temperature
Storage Condition	Recombinant 4-1BB Receptor can be stored in working aliquots at 2? – 8?C for one month, or at -20?C to -70?C for twelve months. Avoid repeated freeze/thaw cycles.