Recombinant Kerela strain Nipah virus Fusion Glycoprotein (partial)
Catalogue Number: 2570002
Pack Size: 100µg
Product Overview
| Species | Henipavirus nipahense |
|---|---|
| Background | This recombinant fusion (F) protein of the Kerala strain of Henipavirus nipahense, expressed in Escherichia coli, represents the viral fusion glycoprotein encoded by the F gene. The F protein plays a central role in viral entry by mediating fusion between the viral and host cell membranes following receptor engagement by the attachment glycoprotein (G), thereby allowing release of the viral genome into the host cell. It requires proteolytic cleavage to attain its fusogenic, active form and undergoes critical conformational changes necessary for membrane fusion. As an essential component of the viral entry apparatus, the F protein constitutes a major antigenic target for neutralizing antibodies and fusion-inhibitory immune responses. This recombinant protein is valuable for applications including serological diagnostics, epitope mapping, monoclonal antibody generation, vaccine and immunogenicity studies, investigations of fusion and entry mechanisms, and structural and functional analyses of Nipah virus fusion proteins. |
| Uniprot ID | A0A3G1QY51 |
| Purity | >85% as determined by SDS-PAGE. |
| Pack Size | 100µg |
Target Sequence
ILHYEKLSKIGLVKGITRKYKIKSNPLTKDIVIKMIPNVSNMSQCTGSVMENYKTRLNGILTPIKGALEIYKNNTHDLVGDVRLAGVIMAGVAIGIATAAQITAGVALYEAMKNADNINKLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINTNLVPTIDKISCKQTELSLDLALSKYLSDLLFVFGPNLQDPVSNSMTIQAISQAFGGNYETLLRTLGYATEDFDDLLESDSITGQIIYVDLSGYYIIVRVYFPILTEIQQAYIQELLPVSFNNDNSEWISIVPNFILVRNTLISNIEIGFCLITKRSVICNQDYATPMTNNMRECLTGSTEKCPRELVVSSHVPRFALSNGVLFANCISVTCQCQTTGRAISQSGEQTLLMIDNTTCPTAVLGNVIISLGKYLGSVNYNSEGIAIGPPVFTDKVDISSQISSMNQSLQQSKDYIKEAQRLLDTVNPSLISMLSM
Stability and Storage
For long-term preservation, the product should be maintained in a lyophilized form at temperatures between −20 °C and −80 °C. To ensure optimal stability, the protein should be aliquoted prior to storage. Once reconstituted, the protein solution may be stored at 2–8 °C for up to 2–7 days.
Reconstitution
The protein may be reconstituted in sterile water to prepare a stock solution. Repeated freeze–thaw cycles should be avoided.
For research use only, not for clinical diagnosis.
