Gene ID |
N/A |
Accession |
NM_006252, NM_006253, NM_002733 |
Alternative Name |
Subunits A2: PRKAA2, AMPK, AMPK2, PRKAA Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G1: PRKAG1, AMPKG, MGC8666 |
Species |
Human |
Source |
Insect cells |
Description |
AMPK (A2/B1/G1) plays a key role in insulin signaling pathway and is a major therapeutic target for the treatment of diabetes . AMPK is viewed as a fuel sensor for glucose and lipid metabolism by modulating the activity of the autonomous nervous system in vivo. Short-term overexpression of a constitutively active form of AMPK in the liver leads to mild hypoglycemia and fatty liver due to increased fatty acid utilization . |
Accession |
NM_006252, NM_006253, NM_002733 |
Functions |
The specific activity of AMPK was determined to be 310 nmol /min/mg as per activity assay protocol. |
Formulation |
50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Solubility |
N/A |
Appearance |
Liquid |
Molecular Weight |
69 |
Purity |
70% – 90% |
Shipping Condition |
Dry Ice |
Storage Condition |
Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |