Gene ID |
N/A |
Accession |
NM_004304 |
Alternative Name |
ALK (Ki-1), CD246, NBLST3, TFG/ALK |
Species |
Human |
Source |
Insect cells |
Description |
?ALK or anaplastic lymphoma kinase is a receptor tyrosine kinase that was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types . In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis . |
Accession |
NM_004304 |
Functions |
The specific activity of ALK was determined to be 24 nmol /min/mg as per activity assay protocol. |
Formulation |
50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Solubility |
N/A |
Appearance |
Liquid |
Molecular Weight |
90 |
Purity |
70% – 90% |
Shipping Condition |
Dry Ice |
Storage Condition |
Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |