Showing 109–117 of 129 results
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Recombinant Human BTK (N-His tag)
Product Details
Gene ID N/A Accession NM_000061 Alternative Name AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK Species Human Source Insect cells Description BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors . Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments .? Accession NM_000061 Functions The specific activity of BTK was determined to be 43 nmol /min/mg as per activity assay protocol. Formulation 50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 78 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK1 delta (N-GST tag)
Product Details
Gene ID N/A Accession NM_153498 Alternative Name RP11-462F15.1; CKLiK; CaM-K1; CaMKID Species Human Source Insect cells Description CAMK1d or Ca2+/calmodulin-dependent kinase I-like kinase (CKLiK) is activated by Ca(2+) and calmodulin and is detected in CD34+-derived neutrophils and eosinophils, as well as in mature peripheral blood granulocytes . CAMK1d exhibits Ca(2+)/CaM-dependent activity that is enhanced in vitro by phosphorylation of its Thr180 by CaM-K kinase (CaM-KK)alpha, consistent with detection of CAMK1D-activating activity in HeLa cells . Accession NM_153498 Functions The specific activity of CAMK1d was determined to be 138 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 68 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK1 gamma (1-330aa) (N-GST tag)
Product Details
Gene ID N/A Accession NM_020439 Alternative Name VWS1; CLICKIII; dJ272L16.1 Species Human Source Insect cells Description CAMKI? (CLICK-III), a member of CAMK family, is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase. Full activation of CaMKI? requires both Ca(2+)/CaM and phosphorylation by CAMKK. CAMKI? transcripts is most abundant in neurons, with the highest levels in limited nuclei such as the central nucleus of the amygdala (CeA) and the ventromedial hypothalamus .? Accession NM_020439 Functions The specific activity of CAMK1? was determined to be 788 nmol /min/mg as per activity assay protocol Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 69 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK1 gamma (N-GST tag)
Product Details
Gene ID N/A Accession NM_020439 Alternative Name VWS1; CLICKIII; dJ272L16.1 Species Human Source Insect cells Description CAMKI? (CLICK-III), a member of CAMK family, is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase. Full activation of CaMKI? requires both Ca(2+)/CaM and phosphorylation by CAMKK. CAMKI? transcripts is most abundant in neurons, with the highest levels in limited nuclei such as the central nucleus of the amygdala (CeA) and the ventromedial hypothalamus . Accession NM_020439 Functions The specific activity of CAMK1? was determined to be 820 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 80 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK2 alpha (N-GST tag)
Product Details
Gene ID N/A Accession NM_171825 Alternative Name CAMKA; KIAA0968 Species Human Source Insect cells Description CAMK2a is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2a is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2a can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2a fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2a increased with heightened neuronal activity .? Accession NM_171825 Functions The specific activity of CAMK2a was determined to be 256 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 74 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK2 delta (N-GST tag)
Product Details
Gene ID N/A Accession NM_172115 Alternative Name CAMKD, MGC44911 Species Human Source Insect cells Description CAMK2D is a serine/threonine protein kinase that is a member of the type II multifunctional Ca2+/calmodulin-dependent protein kinase family. CAMK2D is abundantly present in human cardiac and skeletal muscle and its levels are increased in the heart of patients suffering from cardiomyopathy . In cardiomyocytes, stimulation of beta-1-adrenergic receptor leads to induction of apoptosis, an effect that is mediated by activation of CAMK2D in a PKA-independent manner. In addition, expression studies have revealed the downregulation of CAMK2D in human tumor cells. Accession NM_172115 Functions The specific activity of CAMK2? was determined to be 5,860 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 77 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK2 gamma (N-GST tag)
Product Details
Gene ID N/A Accession NM_172169 Alternative Name CAMKG, CAMK, CAMK-II, MGC26678 Species Human Source Insect cells Description CAMK2? is a member of the CAMKII family which are ubiquitous serine/threonine protein kinases that have been implicated in diverse effects of hormones and neurotransmitters. CAMK2? has six alternatively spliced variants that encode six different isoforms. Some of these variants have been identified in human tumors . Transgenic mice expressing a partially calcium-independent mutant form of CAMKG showed 1.5- to 2-fold increase in the thymus of these mice, at least in part due to an increase in the life span of double-positive thymocytes . There was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype. Accession NM_172169 Functions The specific activity of CAMK2? was determined to be 248 nmol /min/mg as per activity assay protocol Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 60 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK2beta (N-GST tag)
Product Details
Gene ID N/A Accession NM_172081 Alternative Name CAMKB, CAM2, CAMK2, MGC29528 Species Human Source Insect cells Description CAMK2beta belongs to the serine/threonine protein kinase family and to the type II multifunctional Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK2beta showed wide tissue and cell distribution, and one of CAMK2beta variant predominated in adult brain . The ratio of CAMK2alpha and CAMK2beta protein levels were inversely related during activity in hippocampal neurons . CAMK2beta is a prominent kinase in the central nervous system and may function in long-term potentiation and neurotransmitter release. Accession NM_172081 Functions The specific activity of CAMK2? was determined to be 1,700 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 81 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human CAMK2gamma (N-GST tag)
Product Details
Gene ID N/A Accession NM_172169 Alternative Name CAMKG, CAMK, CAMK-II, MGC26678 Species Human Source Insect cells Description CAMK2gamma is a member of the CAMKII family which are ubiquitous serine/threonine protein kinases that have been implicated in diverse effects of hormones and neurotransmitters. CAMK2gamma has six alternatively spliced variants that encode six different isoforms. Some of these variants have been identified in human tumors . Transgenic mice expressing a partially calcium-independent mutant form of CAMK2gamma showed 1.5- to 2-fold increase in the thymus of these mice, at least in part due to an increase in the life span of double-positive thymocytes . There was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype. Accession NM_172169 Functions The specific activity of CAMK2? was determined to be 260 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 86 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No)