Showing 100–108 of 129 results
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Recombinant Human BMP7
Product Details
Gene ID 655 Accession P18075 Alternative Name Osteogenic protein 1, OP-1, INN=Eptotermin alfa, BMP7 <br/>Recombinant Human Bone Morphogenetic Protein 7 (BMP7) Species Human Source E. coli Description BMP-7(osteogenic protein- 1) is produced in the kidney and in the nervous system. It is produced also by human fetal trophoblasts in vivo and may be involved in the regulation of the synthesis of chorionic gonadotropin and progesterone by trophoblasts. BMP7 induces new bone growth, and forms heterodimers with BMP2A. The factor is a member of the TGF family of proteins. Accession P18075 Functions Not available. Formulation Recombinant BMP-7 was lyophilized from a 0.2 ?m filtered PBS solution pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 17 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BMP7
Product Details
Gene ID 655 Accession P18075 Alternative Name Osteogenic protein 1, OP-1, INN=Eptotermin alfa, BMP7 <br/>Recombinant Human Bone Morphogenetic Protein 7 (BMP7) Species Human Source E. coli Description BMP-7(osteogenic protein- 1) is produced in the kidney and in the nervous system. It is produced also by human fetal trophoblasts in vivo and may be involved in the regulation of the synthesis of chorionic gonadotropin and progesterone by trophoblasts. BMP7 induces new bone growth, and forms heterodimers with BMP2A. The factor is a member of the TGF family of proteins. Accession P18075 Functions Not available. Formulation Recombinant BMP-7 was lyophilized from a 0.2 ?m filtered PBS solution pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 17 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BMPR2 (N-His tag)
Product Details
Gene ID N/A Accession NM_001204 Alternative Name BMPR-II; BMPR3; BMR2; BRK-3; FLJ41585; FLJ76945; PPH1; T-ALK Species Human Source Insect cells Description BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis . The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation . Accession NM_001204 Functions The specific activity of BMPR2 was determined to be 14 nmol /min/mg as per activity assay protocol. Formulation 50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 115 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BMX
Product Details
Gene ID N/A Accession NM_001721 Alternative Name Bone marrow tyrosine kinase, ETK, PSCTK2, PSCTK3 Species Human Source Insect Cells Description Recombinant full-length human BMX was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX is found to induce activation of the Stat signalling pathway. Accession NM_001721 Functions The specific activity of BMX was determined to be 34 nmol/min/ml. Formulation Recombinant BMX is stored in 50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% Glycerol at 0.1 μg/?l. Solubility N/A Appearance Liquid Molecular Weight 110 Purity >80% as determined by SDS-PAGE Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BMX (N-GST tag)
Product Details
Gene ID N/A Accession NM_001721 Alternative Name ETK; PSCTK2; PSCTK3 Species Human Source Insect cells Description The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells . The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX, is found to induce activation of the Stat signaling pathway .? Accession NM_001721 Functions The specific activity of BMX was determined to be 34 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 110 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BRAF (N-GST tag)
Product Details
Gene ID N/A Accession NM_004333 Alternative Name BRAF (Ex9-18), BRAF1, RAFB1, B-raf, B-raf 1, MGC126806, MGC138284 Species Human Source Insect cells Description BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRAF in cells responding to growth factor signals . Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 599 within the activation segment of BRAF . Accession NM_004333 Functions The specific activity of BRAF was determined to be 2,300 nmol/min/mg in a coupled assay as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 69 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BRAF (N-GST tag)
Product Details
Gene ID N/A Accession NM_004333 Alternative Name BRAF1, RAFB1, B-raf 1, MGC126806, MGC138284 Species Human Source Insect cells Description BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRaf in cells responding to growth factor signals . Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 599 within the activation segment of B-RAF . Accession NM_004333 Functions The specific activity of BRAF was determined to be 74 nmol /min/mg as per activity assay protocol, using MEK1 as substrate. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 63 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BRK (N-GST tag)
Product Details
Gene ID N/A Accession NM_005975 Alternative Name PTK6; FLJ42088 Species Human Source Insect cells Description ?BRK is a member of the non-receptor tyrosine kinases (PTKs) that contains an amino terminal SH3 and SH2 domain as well as the catalytic domain . BRK expression is low or undetectable in normal mammary tissue and benign lesions. However, approximately two-thirds of breast tumors express appreciable levels, and 27% of tumors over express BRK by fivefold or more .? Accession NM_005975 Functions The specific activity of BRK was determined to be 133 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 80 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human BRSK2 (N-GST tag)
Product Details
Gene ID N/A Accession NM_003957 Alternative Name HUSSY-12, C11orf7; PEN11B; SAD1; STK29 Species Human Source Insect cells Description BRSK2 is a brain-selective serine/threonine kinase 2 that is mainly expressed in the brain, with weaker expression in testis and pancreas. BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C and CDC25B in an in vitro assay. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhanced endogenous BRSK2 kinase activity in a caffeine-sensitive manner and caused translocation of BRSK2 from the cytoplasm to the nucleus . Overexpression of BRSK2 induces G2/M arrest in HeLa cells while small interfering RNA against BRSK2 partly abrogated UV-induced G2/M arrest. Mammalian BRSK2 kinases are required for neuronal polarization . Accession NM_003957 Functions The specific activity of BRSK2 was determined to be 105 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 108 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No)