Showing 91–99 of 142 results
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Recombinant Human BDNF
Product Details
Gene ID 627 Accession P23560 Alternative Name BDNF, Abrineurin<br/>Recombinant Human Brain-Derived Neurotrophic Factor (BDNF) Species Human Source E. coli Description BDNF is found in neurons of the central nervous system. It is expressed predominantly in hippocampus, cortex, and synapses of the basal forebrain. The biological activity of BDNF is mediated by a receptor that belongs to the trk family of receptors encoding a tyrosine-specific protein kinase. BDNF only binds weakly to the gp140trk receptor (to which NGF binds with high affinity), and it binds to the NGF receptor known as LNGFR. BDNF selectively supports the survival of primary sensory neurons and retinal ganglia. The factor supports survival and differentiation of certain cholinergic neurons and also some dopaminergic neurons in vitro. BDNF does not appear to act on sympathetic ganglia. In specific neurons of the central nervous system located in the hippocampus and the cortex the synthesis of BDNF is influenced by neuronal activity either positively (glutamate transmitter system) or negatively (GABA transmitter system). Accession P23560 Functions The ED(50) was determined by the dose-dependent proliferation of rat C6 cells, and was found to be in the range of 0.5 ug/mL. Formulation Recombinant Brain Derived Neurotrophic Factor was lyophilized from a 0.2 ?m filtered citric acid, pH 5.7. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 14 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 1 (DEFB1)
Product Details
Gene ID 1672 Accession P60022 Alternative Name Defensin, beta 1, DEFB1, BD-1, hBD-1 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so form channels which lead to leakage of cytoplasmic molecules and cell death. Human beta-defensin-1, which has 36 amino acids, was originally isolated from hemofiltrates of patients with advanced renal failure. The BD-1 gene is expressed mainly in the urogenital tract and, to a lesser degree, in trachea and lung, BD-1 is believed to function in the antimicrobial defense of the urogenital and respiratory tracts. Accession P60022 Functions The ED50 was determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/mL. Formulation Lyophilized from a 0.2 ?m filtered solution in PBS (pH 8) Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 4.2 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles $0.00(No) -
Recombinant Human Beta-Defensin 1 (DEFB1)
Product Details
Gene ID 1672 Accession P60022 Alternative Name Defensin, beta 1, DEFB1, BD-1, hBD-1 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so form channels which lead to leakage of cytoplasmic molecules and cell death. Human beta-defensin-1, which has 36 amino acids, was originally isolated from hemofiltrates of patients with advanced renal failure. The BD-1 gene is expressed mainly in the urogenital tract and, to a lesser degree, in trachea and lung, BD-1 is believed to function in the antimicrobial defense of the urogenital and respiratory tracts. Accession P60022 Functions The ED(50) was Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/mL. Formulation Recombinant Human beta Defensin-1 was lyophilized from 0.2 ?m filtered 100 mM NaCl, 20 mM PB, pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 4.2 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 1 (DEFB1)
Product Details
Gene ID 1672 Accession P60022 Alternative Name Defensin, beta 1, DEFB1, BD-1, hBD-1 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so form channels which lead to leakage of cytoplasmic molecules and cell death. Human beta-defensin-1, which has 36 amino acids, was originally isolated from hemofiltrates of patients with advanced renal failure. The BD-1 gene is expressed mainly in the urogenital tract and, to a lesser degree, in trachea and lung, BD-1 is believed to function in the antimicrobial defense of the urogenital and respiratory tracts. Accession P60022 Functions The ED50 was determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/mL. Formulation Lyophilized from a 0.2 ?m filtered solution in PBS (pH 8) Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 4.2 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 2 (DEFB4A)
Product Details
Gene ID 1673 Accession O15263 Alternative Name Beta-defensin 4A, BD-2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB102, DEFB2, DEFB4 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so forms channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria. Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession O15263 Functions The ED50 was determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/mL. Formulation Lyophilized from a 0.2 ?m filtered solution in PBS (pH 8) Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 4.6 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 2 (DEFB4A)
Product Details
Gene ID 1673 Accession O15263 Alternative Name Beta-defensin 4A, BD-2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB102, DEFB2, DEFB4 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so forms channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria. Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession O15263 Functions The ED(50) was Determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/mL. Formulation Recombinant Human beta Defensin-2 was lyophilized from 0.2 ?m filtered 100 mM NaCl, 20 mM PB, pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 4 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 2 (DEFB4A)
Product Details
Gene ID 1673 Accession O15263 Alternative Name Beta-defensin 4A, BD-2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB102, DEFB2, DEFB4 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so forms channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria. Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession O15263 Functions The ED50 was determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/mL. Formulation Lyophilized from a 0.2 ?m filtered solution in PBS (pH 8) Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight N/A Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 3 (DEFB103A)
Product Details
Gene ID 55894 Accession P81534 Alternative Name Beta-defensin 3, BD-3, DEFB-3, HBD3, hBD-3, Defensin, beta 103, Defensin-like protein, BD3, DEFB103, DEFB3 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so form channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession P81534 Functions The ED(50) was Determined by its antimicrobial resistance to E.Coli and was determined to be < 3.0 ug/mL. Formulation Recombinant Human beta Defensin-3 was lyophilized from 0.2 ?m filtered 100 mM NaCl, 20 mM PB, pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 5.4 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No) -
Recombinant Human Beta-Defensin 3 (DEFB103A)
Product Details
Gene ID 55894 Accession P81534 Alternative Name Beta-defensin 3, BD-3, DEFB-3, HBD3, hBD-3, Defensin, beta 103, Defensin-like protein, BD3, DEFB103, DEFB3 Species Human Source E. coli Description Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins – which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that the function of defensins in the eradication of pathogens from the host system is to insert themselves into the bacterial membrane under the influence of membrane potential, in doing so form channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing the gram negative bacteria Its expression is also upregulated by the cytokine tumor necrosis factor-alpha. Accession P81534 Functions The ED(50) was Determined by its antimicrobial resistance to E.Coli and was determined to be < 3.0 ug/mL. Formulation Recombinant Human beta Defensin-3 was lyophilized from 0.2 ?m filtered 100 mM NaCl, 20 mM PB, pH 7.4. Solubility A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Appearance Lyophilized Powder Molecular Weight 5.4 Purity >95% as determined by SDS-PAGE Concentration <1.0 EU/μg of recombinant protein as determined by the LAL method. Shipping Condition Ambient Temperature Storage Condition The lyophilized protein is stable for at least one year from date of receipt at -70?C. Upon reconstitution, this cytokine can be stored in working aliquots at 2? – 8?C for one month, or at -20?C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. $0.00(No)