Showing 19–27 of 59 results
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Recombinant Human ALK (N-GST tag)
Product Details
Gene ID N/A Accession NM_004304 Alternative Name ALK (Ki-1), CD246, NBLST3, TFG/ALK Species Human Source Insect cells Description ?ALK or anaplastic lymphoma kinase is a receptor tyrosine kinase that was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types . In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis . Accession NM_004304 Functions The specific activity of ALK was determined to be 24 nmol /min/mg as per activity assay protocol. Formulation 50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 90 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human ALK1 (N-GST tag)
Product Details
Gene ID N/A Accession NM_000020 Alternative Name ACVRL1, ACVRLK1, ALK1, HHT, HHT2, ORW2, SKR3, ALK1, TSR-I Species Human Source Insect cells Description ?ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGF? superfamily . ALK1 functions as a TGF? type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGF? signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported . Accession NM_000020 Functions The specific activity of ALK1 was determined to be 22 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 64 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human ALK2 (N-GST tag)
Product Details
Gene ID N/A Accession NM_001105 Alternative Name ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI Species Human Source Insect cells Description ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGF?RI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells . Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues . Accession NM_001105 Functions The specific activity of ALK2 was determined to be 39 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 67 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human ALK3 (BMPR1A) (N-GST tag)
Product Details
Gene ID N/A Accession NM_004329 Alternative Name ALK3; BMPR1A; 10q23del; ACVRLK3; CD292; SKR5 Species Human Source Insect cells Description ?BMPR1A (also known as bone morphogenetic protein receptor 1A) is a member of the transmembrane serine/threonine kinase family that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A act as a minor susceptibility gene for PTEN-mutation-negative Cowden syndrome. BMPR1A regulates the PTEN protein levels by decreasing PTEN’s association with the degradative pathway . BMPR1A trafficking plays a significant role in FOP pathogenesis and is also involved in human T-cell differentiation . Accession NM_004329 Functions The specific activity of ALK3 (BMPR1A) was determined to be 1.2 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 66 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human ALK4 (N-GST tag)
Product Details
Gene ID N/A Accession NM_004302 Alternative Name ACVR1B, SKR2, ACTRIB, ACVRLK4 Species Human Source Insect cells Description ALK4 is a member of the subfamily of receptor ser/thr kinases that mediates signaling by the Activins. ALK4 is expressed in many human tissues, including kidney, pancreas, brain, lung, and liver. Truncated ALK4, predominantly expressed in human pituitary adenomas, function as dominant negative receptors to interfere with wild-type receptor function and blocks the antiproliferative effect of activin possibly contributing to development of human pituitary tumors . ALK4 is able to mediate Nodal signaling in the presence of Cripto during vertebrate development . Accession NM_004302 Functions The specific activity of ALK4 was determined to be 16 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 64 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human ALK6 (BMPR1B) (N-GST tag)
Product Details
Gene ID N/A Accession NM_001203 Alternative Name ALK-6; ALK6; CDw293 Species Human Source Insect cells Description ALK6 (also known as BMPR1B) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. ALK6 is mainly involved in the endochondral bone formation and embryogenesis. ALK6 expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients . ALK6 receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation . Accession NM_001203 Functions The specific activity of ALK6 (BMPR1B) was determined to be 23 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 68 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human AMPK (A1/B1/G1) (C-His tag)
Product Details
Gene ID N/A Accession NM_006251, NM_006253, NM_002733 Alternative Name Subunit A1: PRKAA1, MGC33776, MGC57364 Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G1: PRKAG1, AMPKG, MGC8666 Species Human Source Insect cells Description AMPK is a heterotrimer protein kinase consisting of an a catalytic subunit, and non-catalytic ? and ? subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status . In response to cellular metabolic stresses, AMPK is activated and phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating biosynthesis of fatty acid and cholesterol . Accession NM_006251, NM_006253, NM_002733 Functions The specific activity of AMPK was determined to be 737 nmol /min/mg as per activity assay protocol. Formulation 50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 68 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No) -
Recombinant Human AMPK (A1/B1/G2) (C-His tag)
Product Details
Gene ID N/A Accession NM_006251, NM_006253, NM_001040633 Alternative Name Subunit A1: PRKAA1, MGC33776, MGC57364 Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G2: PRKAG2, AAKG, CMH6, WPWS, AAKG2, H91620p Species Human Source Insect cells Description AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis . AMPK exists as a heterotrimeric complex composed of a catalytic a subunit and regulatory ? and ? subunits. Binding of AMP to the ? subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) and via signaling pathways in response to adiponectin, leptin and CAMKK?. Accession NM_006251, NM_006253, NM_001040633 Functions The specific activity of AMPK was determined to be 980 nmol /min/mg as per activity assay protoco Formulation 50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 68 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles ₹0.00(No) -
Recombinant Human AMPK (A1/B1/G2) (N-GST/C-His tag)
Product Details
Gene ID N/A Accession NM_006251, NM_006253, NM_001040633 Alternative Name Subunit A1: PRKAA1, MGC33776, MGC57364 Subunit B1: PRKAB1, AMPK, HAMPKb, MGC17785 Subunit G2: PRKAG2, AAKG, CMH6, WPWS, AAKG2, H91620p Species Human Source Insect cells Description ?AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis . AMPK exists as a heterotrimeric complex composed of a catalytic alpha subunit and regulatory beta and gamma subunits. Binding of AMP to the gamma subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) and via signaling pathways in response to adiponectin, leptin and CAMKKbeta. Accession NM_006251, NM_006253, NM_001040633 Functions The specific activity of AMPK was determined to be 725 nmol /min/mg as per activity assay protocol. Formulation 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. Solubility N/A Appearance Liquid Molecular Weight 92 Purity 70% – 90% Shipping Condition Dry Ice Storage Condition Store product at ?70?C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. ₹0.00(No)